Structural Descriptors for Subunit Interface Regions in Homodimers: Effect of Lipid Membrane and Secondary Structure Type.

ABSTRACT: A total of 1311 homodimers were collected and analyzed in three different categories to highlight the impact of lipid environment and secondary structure type: 422 cytoplasmic α-helix, 411 cytoplasmic β-strand, and 478 membrane complexes. Structural features of the interface connecting two monomers were investigated and compared to those of the non-interface surface. Every residue on the surface of each monomer was explored based on four attributes: solvent-accessible surface area (SASA), protrusion index (C_x), surface planarity, and surface roughness. SASA and C_x distribution profiles clearly distinguished the interface from the surface in all categories, where the rim of the interface displayed higher SASA and C_x values than the rest

SUBMITTER: Yuksek A 

PROVIDER: S-EPMC12004529 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature