The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure.

ABSTRACT:

Background

As the World Trade Center (WTC) General Responder Cohort ages, it is imperative to study their aging process and identify factors that can be targeted for interventions.

Objectives

Our goal was to utilize a previously developed WTC Clinical Frailty Index (CFI) to identify distinct frailty trajectories and associated factors in this cohort.

Design

A latent class mixed model evaluated frailty trajectories using WTC CFIs. Multinomial regression models were used to assess associations between frailty trajectory and sociodemographic and WTC characteristics.

Setting

We utilized data collected during routine WTC monitoring visits from 2004 until 2021.

Participants

The participants were WTC general responders.

Measurements

Relative risk ratios

SUBMITTER: Thompson HM 

PROVIDER: S-EPMC12004615 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature