Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy.

ABSTRACT:

Background

Systemic insulin resistance plays an important role in the pathogenesis of type 2 diabetes and its complications. Although impaired branched-chain amino acid (BCAA) metabolism has been reported to be involved in the development of diabetes, the relationship between cardiac BCAA metabolism and the pathogenesis of diabetic cardiomyopathy (DbCM) remains unclear.

Objectives

The aim of this study was to investigate BCAA metabolism in insulin-resistant hearts by using a novel mouse model of DbCM.

Methods

The cardiac phenotypes of adipocyte-specific 3'-phosphoinositide-dependent kinase 1 (PDK1)-deficient (A-PDK1KO) mice were assessed by histological analysis and echocardiography. The metabolic characteristics and cardiac gene expression were determined by mass spe

SUBMITTER: Asakura J 

PROVIDER: S-EPMC12004671 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature