[Effect of low-dose primaquine treatment on Plasmodium vivax recurrence and transmission-blocking activity in southwest Ethiopia: a longitudinal cohort study.

ABSTRACT:

Background

Existing malaria control strategies for Plasmodium vivax are challenging due to its dormant and relapsing liver stages, as well as the early onset of gametocytogenesis. Primaquine (PQ) effectively eliminates dormant stages and can kill gametocytes; however, it necessitates repeated dosing. In this study, the effectiveness of chloroquine (CQ) plus low-dose of PQ on recurrence and its transmission-blocking activity was evaluated.

Methods

Between September 2019 and July 2022, a prospective cohort study was conducted in the Jimma-Arjo and Dabo-Hanna districts of the Oromia region in Ethiopia. A total of 214 uncomplicated cases of P. vivax malaria were enrolled in the study. Participants were treated with either CQ alone (106) or CQ + PQ (108), based on whether their d

SUBMITTER: Getachew H 

PROVIDER: S-EPMC12004725 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature