Transcriptomic profiles of Crandell-Rees feline kidney cells infected with Varicellovirus felidalpha-1 (FHV-1) field and vaccine strains.

ABSTRACT:

Background

Varicellovirus felidalpha-1 (FHV-1, previously Felid alphaherpesvirus-1) is a significant cause of upper respiratory tract disease in feline populations. Cats infected with FHV-1 show clinical signs that vary in severity. This can be due to differences in host responses and virus strain virulence. Investigating the gene transcription profiles during infections using FHV-1 strains could inform our understanding of host and viral factors contributing to disease outcomes. This study characterised the transcriptomes of Crandell-Rees feline kidney (CRFK) cells infected with field or vaccine FHV-1 strains to better understand the host response during infection.

Methods

Crandell-Rees feline kidney cells were infected with either the FHV-1 F2 vaccine strain or the 384/75

SUBMITTER: Kwan E 

PROVIDER: S-EPMC12004785 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature