Risk factors for administration of additional neuromuscular block reversal in adults undergoing general anaesthesia: a single centre retrospective case-control study.

ABSTRACT:

Background

Residual neuromuscular block continues to be a modifiable risk factor for major postoperative pulmonary complications in adults.

Methods

We performed a large retrospective case-control study at a single center to evaluate both the prevalence and risk factors for clinically significant residual neuromuscular block following reversal with neostigmine.

Results

We found that clinically significant residual neuromuscular block after reversal with neostigmine is rare, occurring in 3.2% of adults. Risk factors for incomplete reversal with neostigmine following rocuronium administration included: increasing age, ASA physical class status III and IV, a cumulative dose of rocuronium > 0.43 mg•kg^-1hr^-1, an interval of < 48 min between the last do

SUBMITTER: Vishneski SR 

PROVIDER: S-EPMC12004803 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature