6-Methoxyflavone inhibits glycolytic energy metabolism in HeLa cells.

ABSTRACT:

Background

Enhanced glycolytic levels in cancer cells are a common characteristic of many cancer types. Modulation of glycolytic metabolism is crucial for enhancing the efficacy of cancer therapy. The specific role of 6-methoxyflavone in regulating glycolytic metabolism in cancer cells remains unclear. This study aimed to elucidate the impact of 6-methoxyflavone on glycolytic metabolism in cervical cancer cells and its clinical relevance.

Methods

The tandem mass tag (TMT) proteomic analysis was used to identify significantly enriched biological processes and pathways in HeLa cells after treatment with 6-methoxyflavone. Additionally, the differential expression of glycolysis-related proteins was validated using parallel reaction monitoring (PRM) proteomics. Untargeted and tar

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12004806 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature