Non-linear relationship between serum α-Klotho and suicide attempt: evidence from a large never-smoking population.

ABSTRACT:

Background

Recent study has demonstrated decreased α-Klotho expression in brain regions associated with suicide, including the hippocampus and prefrontal cortex. While serum α-Klotho emerges as a potential mental health biomarker, its relationship with suicidal ideation remains unclear, particularly in never-smokers where smoking's confounding effects are eliminated.

Methods

Data from 5,710 lifetime non-smokers were analyzed using the National Health and Nutrition Examination Survey (NHANES) were analyzed, with smoking status verified through detailed questionnaires. Multiple logistic regression models were employed to examine the association between serum α-Klotho and suicidal ideation. Generalized additive models and threshold effect analyses were conducted to explore non-

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12004823 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature