All-cause and cause-specific mortality in respiratory symptom clusters: a population-based multicohort study.

ABSTRACT:

Background

Respiratory symptoms are common in the general adult population. Increased burden of respiratory symptoms may increase the risk of mortality. We assessed the association between respiratory symptom clusters and mortality.

Methods

Participants were derived from two population-based Swedish adult cohorts (N = 63,060). Cluster analysis was performed with Locality Sensitive Hashing (LSH)-k-prototypes in subjects with ≥ 1 self-reported respiratory symptom. Linked mortality register data (up to 21 years of follow-up, > 600,000 person-years) were used. Associations between clusters and all-cause/cause-specific mortality were assessed using asymptomatic subjects as reference.

Results

Over 60% reported ≥ 1 respiratory symptom and ~ 30% reported ≥ 5 respiratory sympt

SUBMITTER: Lisik D 

PROVIDER: S-EPMC12004835 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature