A Library of Polyphenol-Amino Acid Condensates for High-Throughput Continuous Flow Production of Nanomedicines with Ultra-High Drug Loading.

ABSTRACT: Synthesizing high drug-loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large-scale engineered production of such nanomedicines presents even greater difficulties. This study presents a scalable library of polyphenol-amino acid condensates. By selecting amino acids, the library enables precise customization of key properties, such as carrier capacity, bioactivity, and other critical attributes, offering a versatile range of options for various application scenarios. Leveraging the properties of solvent-mediated disassembly and reassembly of condensates achieved an ultra-high drug loading of 86% for paclitaxel. For a range of poorly soluble molecules, the drug loading capacity exceeded 50%, indicating broad applicability. Furthermore, e

SUBMITTER: Yi Z 

PROVIDER: S-EPMC12004891 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature