Nanodiamond-Based Spatial-Temporal Deformation Sensing for Cell Mechanics.

ABSTRACT: Precise assessment of the mechanical properties of soft biological systems at the nanoscale is crucial for understanding physiology and pathology and developing relevant drugs. Conventional atomic force microscopy (AFM)-based indentation methods suffer from uncertainties in local tip-sample interactions and the model choice. This can be overcome by adopting spatially resolved nonlocal deformation sensing for mechanical analysis. However, the technique is currently limited to lifeless/static systems due to the inadequate spatial or temporal resolution or difficulties in differentiating the indentation-induced deformation from that associated with live activities and other external perturbations. Here, we develop a dynamic nonlocal deformation sensing approach allowing both spatially and tem

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12004926 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature