Carboxysome Shell Protein CcmK2 Assembles into Monodisperse and pH-Reversible Microparticles.

ABSTRACT: Synthetic nano- and microparticles have become essential tools in biotechnology. Protein-based compartments offer distinct advantages over synthetic particles, such as biodegradability and biocompatibility, but their development is still in its infancy. Bacterial microcompartments (BMCs) are protein-based organelles consisting of a protein shell encapsulating an enzymatic core. BMCs are self-assembling, selectively permeable, and modular, making them ideal candidates for the development of protein compartments for biotechnology. Indeed, several groups have engineered BMC shells and individual shell proteins into synthetic nanoreactors and functionalized molecular scaffolds. Expanding the variety of architectures assembled from BMC shell proteins will increase their versatility as building

SUBMITTER: Mak CA 

PROVIDER: S-EPMC12004938 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature