Calprotectin elicits aberrant iron starvation responses in <i>Pseudomonas aeruginosa</i> under anaerobic conditions.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen that uses several mechanisms to survive in the iron-limiting host environment. The innate immune protein calprotectin (CP) sequesters ferrous iron [Fe(II)], among other divalent transition metal ions, to limit its availability to pathogens. CP levels are increased in individuals with cystic fibrosis (CF), a hereditary disease that leads to chronic pulmonary infection by P. aeruginosa. We previously showed that aerobic CP treatment of P. aeruginosa induces a multi-metal starvation response that alters expression of several virulence properties. However, the CF lung is a hypoxic environment due to the growth of P. aeruginosa in dense biofilms. Here, we report that anaerobic CP treatment of P. aeruginosa in

SUBMITTER: Weiner JM 

PROVIDER: S-EPMC12004955 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature