LOX-1 rewires glutamine ammonia metabolism to drive liver fibrosis.

ABSTRACT:

Objective

Liver fibrosis is a crucial condition for evaluating the prognosis of chronic liver disease. Lectin-1ike oxidized low density lipoprotein receptor-1 (LOX-1) has been shown potential research value and therapeutic targeting possibilities in different fibrotic diseases. However, the role of LOX-1 and the underlying mechanisms in liver fibrosis progression remain unclear.

Methods

LOX-1 expression was detected in liver tissues from patients and rodents with liver fibrosis. LOX-1 knockout rats were subjected to CCl₄ or methionine and choline-deficient diet (MCD) to induce liver fibrosis. Transcriptomic and metabolomics analysis were used to investigate the involvement and mechanism of LOX-1 on liver fibrosis.

Results

We found that LOX-1 exacerbated liv

SUBMITTER: Huang R 

PROVIDER: S-EPMC12004974 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature