Effect of Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers.

ABSTRACT: Rationale: The association between fine particulate matter (particulate matter ⩽2.5 μm in aerodynamic diameter, PM_2.5) and lung cancer incidence in nonsmokers (LCINS) remains inconsistent. Objectives: To investigate the association between long-term PM_2.5 exposure and LCINS in a Chinese population and to assess the modifying effect of genetic factors. Methods: Time-dependent Cox proportional hazard models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) of PM_2.5 with LCINS risk and LCINS-related mortality. The polygenic risk score was constructed to further explore the interactions between genetic risk and PM_2.5 exposure. In addition, the population attributable fraction of PM_2.5 to

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12005023 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature