MrgprC11⁺ Jugular Neurons Control Airway Hyperresponsiveness in Allergic Airway Inflammation.

ABSTRACT: The lung is densely innervated by sensory nerves, the majority of which are derived from the vagal sensory neurons. Vagal ganglia consist of two different ganglia, termed nodose and jugular ganglia, with distinct embryonic origins, innervation patterns, and physiological functions in the periphery. Because nodose neurons constitute the majority of the vagal ganglia, our understanding of the function of jugular nerves in the lung is very limited. This study aims to investigate the role of MrgprC11⁺ jugular sensory neurons in a mouse allergic asthma model. Our previous study has shown that MrgprC11⁺ jugular neurons mediate cholinergic bronchoconstriction. In this study, we found that, in addition to MrgprC11, several other Mrgpr family members, including M

SUBMITTER: Xing Y 

PROVIDER: S-EPMC12005045 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature