Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice.

ABSTRACT:

Background

Neonatal porcine islets (NPIs) can mature into a mixed population of endocrine cells that can restore glucose control in mice, pigs, and non-human primates, representing a potential alternative islet source for clinical beta cell replacement therapy. However, it remains unclear how conditions in the recipient influence the maturation and function of these cells. Here, we investigated the impact of host sex on NPIs implanted under the kidney capsule of male and female B6.129S7-Rag1^tm1Mom (B6/Rag^-/-) mice.

Methods

Diabetic mice were transplanted with 3000 NPIs under the kidney capsule. All mice were monitored for reversal of hyperglycemia and glucose clearance at 8- and 20-weeks post-transplant. Grafts were assessed for cell composition and ins

SUBMITTER: Cuesta-Gomez N 

PROVIDER: S-EPMC12005065 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature