DEP domain‑containing 1 is a prognostic biomarker associated with the cell cycle in gliomas.

ABSTRACT: Glioma is the most common primary tumor in the intracranial region, accounting for more than one-half of all central nervous system tumors. Abnormal expression of key cancer genes often promotes the occurrence and development of tumors. DEP domain containing 1 (DEPDC1) is a gene that encodes a protein containing a DEP domain, which serves an important role in numerous biological processes. In the present study, the relationship between the expression level of DEPDC1 and the clinical features of glioma was explored in datasets from the China Glioma Genome Atlas Project. Kaplan-Meier survival analysis was performed to evaluate the value of DEPDC1 expression in the prognosis of patients with glioma. T-test and univariate Cox analysis were used to identify differential genes, and Gene Ontology

SUBMITTER: Li H 

PROVIDER: S-EPMC12005072 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature