Dendritic Cells in Xenotransplantation: Shaping the Cellular Immune Response Toward Tolerance.

ABSTRACT: The molecular barriers that cause acute xenograft rejection have been identified and addressed by generating genetically modified (GM) animals, knocked out for specific xenoantigens (xenoAgs), and expressing regulatory molecules for both complement and coagulation pathways among others. The focus of xenotransplantation research now lies in delayed xenograft rejection. Dendritic cells (DC) are a specific subpopulation of professional antigen-presenting cells (APC) that play a crucial role in the context of organ transplantation. DCs, originating from both the xenograft and the recipient, have the capacity to present xenoAgs to the recipient's immune system via their respective major histocompatibility complex (MHC) molecules leading to rejection. These processes are known as direct and indi

SUBMITTER: Puga Yung GL 

PROVIDER: S-EPMC12005074 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature