RF Heating Effects in CEST NMR with Hyperpolarized ¹²⁹Xe Considering Different Spin Exchange Kinetics and Saturation Schemes.

ABSTRACT: Chemical exchange saturation transfer (CEST) improves the sensitivity of NMR but depending on the spin exchange kinetics, it can require substantial RF energy deposition to label magnetization. Potential side effects like RF-induced heating may occur and must be monitored. Here, we explore the parameter space considering not only undesired heating but also efficient CEST build-up (depolarization rate), spectral resolution (line width), and subsequent effects like changes in chemical shifts of CEST responses. We present a systematic study to compare conventional block pulse with shaped-pulse saturation and quantify how the effective average saturation power impacts these parameters. Pulse shape and nominal excitation bandwidth, however, turned out to have little impact on acquired z-spectra

SUBMITTER: Hernandez-Solarte D 

PROVIDER: S-EPMC12005132 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature