SURFBAT: a surrogate family based association test building on large imputation reference panels.

ABSTRACT: Genotype-phenotype association tests are typically adjusted for population stratification using principal components that are estimated genome-wide. This lacks resolution when analyzing populations with fine structure and/or individuals with fine levels of admixture. This can affect power and precision, and is a particularly relevant consideration when control individuals are recruited using geographic selection criteria. Such is the case in France where we have recently created reference panels of individuals anchored to different geographic regions. To make correct comparisons against case groups, who would likely be gathered from large urban areas, new methods are needed. We present SURFBAT (a surrogate family based association test), which performs an approximation of the transmission-

SUBMITTER: Herzig AF 

PROVIDER: S-EPMC12005154 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature