Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer.

ABSTRACT:

Background

Laryngeal cancer (LC) is a prevalent head and neck carcinoma. Extensive research has established a link between immune cells in the tumor microenvironment (TME) and cancer progression, as well as responses to immunotherapy. This study aims to develop a prognostic model based on immune cell-related genes and examine the TME in LC.

Methods

RNA-seq data for LC were sourced from The Cancer Genome Atlas (TCGA), and GSE27020 and GSE51985 datasets were retrieved from the Gene Expression Omnibus (GEO) database. Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. The prognostic

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12005187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature