CT-based artificial intelligence system complementing deep learning model and radiologist for liver fibrosis staging.

ABSTRACT: Noninvasive methods for liver fibrosis staging are urgently needed due to its significance in predicting significant morbidity and mortality. In this study, we developed an automated DL-based segmentation and classification model (Model-C). Test-time adaptation was used to address data distribution shifts. We then established a deep learning-radiologist complementarity decision system (DRCDS) via a decision model determining whether to adopt Model-C's diagnosis or defer to radiologists. Model-C (AUCs of 0.89-0.92) outperformed models based on liver (AUCs: 0.84-0.90) or spleen (AUCs: 0.69-0.70). With test-time adaptation, the Obuchowski index values of Model-C in three external sets improved from 0.81, 0.73, and 0.73 to 0.85, 0.85, and 0.81. DRCDS performed slightly better than Model-C or s

SUBMITTER: Zheng S 

PROVIDER: S-EPMC12005311 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature