Mycobacterium susceptibility to ivermectin by inhibition of eccD3, an ESX-3 secretion system component.

ABSTRACT: Drug-resistant tuberculosis is a pressing global health issue that requires the development of new drugs or the identification of new therapeutic targets. The ESX-3 secretion system is essential for the Mycobacterium tuberculosis growth and plays a role in iron/zinc homeostasis and virulence. The aim of this study was to evaluate the quaternary interface of EccD3, a component of the ESX-3 secretion system, and to evaluate the association of an eccD3 mutant with drug resistance. The molecular structures of EccD3 protein and other ESX-3 secretion system proteins of the M. tuberculosis were predicted based in homology with the Mycolicibacterium smegmatis tertiary protein structures. According to the in silico results, selamectin, avermectin, ivermectin, and moxidectin were selected as prospec

SUBMITTER: Granados-Tristan AL 

PROVIDER: S-EPMC12005495 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature