CT features and histogram analysis of non-contrast images for differentiating malignant and benign mediastinal lymph nodes in Non-Small Cell Lung Cancer (NSCLC).

ABSTRACT:

Objective

To evaluate the diagnostic value of CT features and histogram analysis in distinguishing between malignant and benign mediastinal lymph nodes in patients with non-small cell lung cancer (NSCLC).

Method

This retrospective study analyzed non-contrast chest CT images from 40 NSCLC patients, comprising 80 pathology-proven mediastinal lymph nodes (46 benign, 34 metastasis). Morphologic features, including size, shape, margins, and internal composition, were independently assessed by two radiologists. Histogram analysis was conducted using the Synapse Vincent system with six parameters: mean attenuation, mean positive pixel (MPP), standard deviation (SD), skewness, kurtosis, and entropy. Statistical analysis included the Mann-Whitney test for continuous data, Fisher's ex

SUBMITTER: Prakaikietikul P 

PROVIDER: S-EPMC12005500 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature