Resveratrol decreases extracellular traps (ETs) in acute promyelocytic leukemia (NB4) cells.

ABSTRACT:

Background

Activated neutrophils can create structures known as neutrophil extracellular traps (NETs/ETs) consisting of nuclear components and granules. The ETOsis phenomenon leads to activating the platelets and coagulation factors. Accordingly, coagulation and fibrinolysis can be promoted. Resveratrol (RSV) is a botanical antioxidant with anti-inflammatory and anti-leukemia effects. The present study was conducted to assess the effect of RSV on the occurrence of ETOsis in the NB4 cell line.

Methods

Human acute promyelocytic leukemia cell line (NB4) were stimulated and treated by lipopolysaccharides (LPS) and RSV, respectively. Sytox green and a fluorescent microscope were used to assess the ETOsis in NB4 cells. Furthermore, the expression level of peptidylarginine deiminas

SUBMITTER: Vafajoo M 

PROVIDER: S-EPMC12005550 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature