Association of migraine treatments with reduced ischemic stroke risk: Evidence from two large-scale real-world data analyses.

ABSTRACT:

Objective

To compare the risk of ischemic stroke in patients with migraine treated with first-line medications, including valproate, topiramate, metoprolol, timolol, or propranolol, versus those not receiving these treatments, using data from two large electronic health records datasets.

Background

The impact of first-line migraine medications on ischemic stroke risk in patients with migraine remains uncertain, highlighting the need for further investigation.

Methods

We conducted a retrospective case-control study using data from Vanderbilt University Medical Center (VUMC) and the All of Us Research Program. Cases were patients with a primary ischemic stroke diagnosis after their first migraine diagnosis, while controls had no ischemic stroke following their initial m

SUBMITTER: Jeong E 

PROVIDER: S-EPMC12005616 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature