Cell type-specific driver lines targeting the <i>Drosophila</i> central complex and their use to investigate neuropeptide expression and sleep regulation.

ABSTRACT: The central complex (CX) plays a key role in many higher-order functions of the insect brain including navigation and activity regulation. Genetic tools for manipulating individual cell types, and knowledge of what neurotransmitters and neuromodulators they express, will be required to gain mechanistic understanding of how these functions are implemented. We generated and characterized split-GAL4 driver lines that express in individual or small subsets of about half of CX cell types. We surveyed neuropeptide and neuropeptide receptor expression in the central brain using fluorescent in situ hybridization. About half of the neuropeptides we examined were expressed in only a few cells, while the rest were expressed in dozens to hundreds of cells. Neuropeptide receptors were expressed more br

SUBMITTER: Wolff T 

PROVIDER: S-EPMC12005719 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature