Neural population dynamics underlying evidence accumulation in multiple rat brain regions.

ABSTRACT: Accumulating evidence to make decisions is a core cognitive function. Previous studies have tended to estimate accumulation using either neural or behavioral data alone. Here, we develop a unified framework for modeling stimulus-driven behavior and multi-neuron activity simultaneously. We applied our method to choices and neural recordings from three rat brain regions-the posterior parietal cortex (PPC), the frontal orienting fields (FOF), and the anterior-dorsal striatum (ADS)-while subjects performed a pulse-based accumulation task. Each region was best described by a distinct accumulation model, which all differed from the model that best described the animal's choices. FOF activity was consistent with an accumulator where early evidence was favored while the ADS reflected near perfect

SUBMITTER: DePasquale B 

PROVIDER: S-EPMC12005723 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature