Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation.

ABSTRACT: Apical constriction is a basic mechanism for epithelial morphogenesis, making columnar cells into wedge shape and bending a flat cell sheet. It has long been thought that an apically localized myosin generates a contractile force and drives the cell deformation. However, when we tested the increased apical surface contractility in a cellular Potts model simulation, the constriction increased pressure inside the cell and pushed its lateral surface outward, making the cells adopt a drop shape instead of the expected wedge shape. To keep the lateral surface straight, we considered an alternative model in which the cell shape was determined by cell membrane elasticity and endocytosis, and the increased pressure is balanced among the cells. The cellular Potts model simulation succeeded in repro

SUBMITTER: Yamashita S 

PROVIDER: S-EPMC12005724 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature