NIR-II Emissive Persistent Neutral π-Radical with Rapid Doublet Internal Conversion for Efficient Cancer Photothermal Theranostics.

ABSTRACT: Organic radicals are considered prospective materials for near-infrared (NIR) photothermal applications, however, sustainability remains the major obstacle of recently reported ionic radical photothermal agents. This work achieved robust sustainability on a series of neutral π-radicals through rational design donor (D)-acceptor (A). With efficient doublet internal conversion, 10H-spiro(acridine-9,9'-fluorene) (SFA)-BTM presented strong NIR absorption extended to 1000 nm and efficient non-radiative relaxation. SFA-BTM nanoparticles (NPs) realized comparable NIR-I photothermal conversion efficiency (PCE) and photoacoustic sensitivity. Also, the π-radical NPs displayed NIR-II emission and achieved high-resolution whole-body angiography for the first time by the NIR-II bioimaging. Ultimately,

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12005734 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature