Mucous Permeable Nanoparticle for Inducing Cuproptosis-Like Death In Broad-Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia.

ABSTRACT: The emergence of antibiotic-resistant bacteria has exacerbated the challenge of treating infectious diseases. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, presents a target for novel therapies. Cuproptosis death is a innovation mode of death, however, this effect may be partially inhibited by glutathione (GSH). Buthionine sulfoximine (BSO) is responsible for GSH biosynthesis and has been identified as a potential promoter of cuproptosis death. Here, Cu₂O-BSO NPs with lung adhesion and mucus penetration ability are synthesized by incorporating BSO onto Cu₂O, and modifying it with DOPA and PEG. Cu₂O-BSO NPs demonstrated a broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bac

SUBMITTER: Hu H 

PROVIDER: S-EPMC12005761 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature