Tunable Hierarchically Porous Gadolinium-Based Metal-Organic Frameworks for Bacteria-Targeting Magnetic Resonance Imaging and In Situ Anti-Bacterial Therapy.

ABSTRACT: Currently, there are no non-invasive tools to accurately diagnose deep surgical site bacterial infections before they cause significant anatomical damage in the clinic. An urgent need exists for bacteria-targeting bifunctional probes for the detection of deep bacterial infections and precise in situ treatment. Herein, the bacteria-targeting 1-borono-3,5-benzenedicarboxylic acid (BBDC) ligand and paramagnetic Gd^3 + into one single metal-organic frameworks (MOFs) are integrated, synergistically realizing bacteria-specific magnetic resonance imaging (MRI) diagnosis and MRI-guided antibacterial treatment. Molecular simulations and nitrogen adsorption-desorption experiments demonstrate that a hierarchical porous structure can be constructed by tuning the Gd^{3 +} /BBDC ratio,

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12005816 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature