L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells.

ABSTRACT: The rising prevalence of heat stress (HS), because of global warming, presents a considerable challenge to both human and animal health and welfare. L-Theanine (LTA), a naturally occurring amino acid, may enhance poultry muscle yield and quality, suggesting its potential application in alleviating the negative impacts of HS. However, the molecular mechanisms through which LTA exerts its beneficial effects remain to be fully understood. This study explored the protective effects of LTA on cultured broiler skeletal muscle cells under oxidative stress induced by HS, focusing on the molecular mechanisms involved. Our findings indicate that treatment with LTA significantly improved cell survival, bolstered the activity of antioxidant enzymes, decreased reactive oxygen species (ROS) contents and

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12005892 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature