Engineering <i>Pseudomonas putida</i> for production of 3-hydroxyacids using hybrid type I polyketide synthases.

ABSTRACT: Engineered type I polyketide synthases (T1PKSs) are a potentially transformative platform for the biosynthesis of small molecules. Due to their modular nature, T1PKSs can be rationally designed to produce a wide range of bulk or specialty chemicals. While heterologous PKS expression is best studied in microbes of the genus Streptomyces, recent studies have focused on the exploration of non-native PKS hosts. The biotechnological production of chemicals in fast growing and industrial relevant hosts has numerous economic and logistic advantages. With its native ability to utilize alternative feedstocks, Pseudomonas putida has emerged as a promising workhorse for the sustainable production of small molecules. Here, we outline the assessment of P. putida as a host for the e

SUBMITTER: Schmidt M 

PROVIDER: S-EPMC12005932 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature