Sex- and region-dependent neuroinflammation in Alzheimer's disease.

ABSTRACT:

Introduction

Despite known sex differences in immune function and Alzheimer's disease (AD), most studies of neuroinflammation in AD have not been analyzed by sex.

Methods

We performed quantitative in vitro autoradiography of hippocampus, entorhinal cortex, and parietal cortex using [³H]-PK1195 and [¹⁸F]-T807. Proinflammatory microRNA (miRNA) expression in parietal cortex was measured by quantitative polymerase chain reaction (qPCR).

Results

We found significant, region-dependent elevations of translocator protein (TSPO) density in AD relative to cognitively normal (CN) and mild cognitive impairment (MCI) in women but not men. Density of tau was increased in AD relative to CN and MCI in both sexes, but only women showed a significant positive corr

SUBMITTER: Acosta-Martinez M 

PROVIDER: S-EPMC12005983 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature