A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors.

ABSTRACT:

Objective

Parathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare malignant parathyroid disorders with varying degrees of recurrence risk. The aim of this study was to determine an effective model for discriminating PC/APT among solitary parathyroid lesions.

Methods

A total of 439 patients with histologically confirmed primary hyperparathyroidism were retrospectively enrolled. The training cohort comprised 207 patients, the validation cohort comprised 52 patients from Hospital I, and the external validation cohort comprised 180 patients from Hospital II. All patients were diagnosed in the parathyroid adenoma (PA) group and the APT/PC group. The clinical and ultrasonic features of the two patient groups were compared. Multivariate logistic regression analysis

SUBMITTER: Liu C 

PROVIDER: S-EPMC12005988 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature