Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence.

ABSTRACT:

Background

It is inaccurate to reflect the level of dust exposure through working years. Furthermore, identifying a predictive indicator for lung function decline is significant for coal miners. The study aimed to explored whether club cell secretory protein (CC16) levels can reflect early lung function changes.

Methods

The cumulative respiratory dust exposure (CDE) levels of 1,461 coal miners were retrospectively assessed by constructed a job-exposure matrix to replace working years. Important factors affecting lung function and CC16 were selected by establishing random forest models. Subsequently, the potential of CC16 to reflect lung injury was explored from multiple perspectives. First, restricted cubic spline (RCS) models were used to compare the trends of changes in lu

SUBMITTER: Wei J 

PROVIDER: S-EPMC12006028 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature