Harnessing computational immunology to design targeted subunit vaccines for infectious bursal disease in poultry.

ABSTRACT:

Introduction

Infectious bursal disease (IBD), caused by the infectious bursal disease Q8 virus (IBDV), is a highly contagious disease in young chickens, leading to immunosuppression with great economic importance. IBDV, a non-enveloped virus with a bipartite dsRNA genome, infects the bursa of Fabricius, causing severe gastrointestinal disease. Effective vaccines are urgently needed due to the limitations of current oral vaccines, including gastrointestinal degradation and low immunogenicity. This study designs and evaluates a multiepitope subunit vaccine using immunoinformatics.

Methods

Sequences of the IBDV structural proteins VP2 and VP3 were obtained from the National Centre for Biotechnology Information) NCBI. These are structural proteins VP2 and VP3 were subjected to t

SUBMITTER: Oladipo EK 

PROVIDER: S-EPMC12006097 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature