Plasma nontargeted metabolomics study of H1N1 and H3N2 influenza in children.

ABSTRACT:

Background

This study used a nontargeted metabolomic approach to investigate small molecular metabolites in the peripheral blood of pediatric patients with influenza. By comparing these metabolites with those in healthy children, potential biomarkers for the early detection and diagnosis of influenza were explored.

Methods

Plasma samples were collected from 47 children with H1N1 influenza, 40 with H3N2 influenza, and 40 healthy controls at Xi'an Children's Hospital, Xi'an Jiaotong University Second Affiliated Hospital, and Xi'an Central Hospital between May and September 2023. Nontargeted metabolomic detection and analysis were performed.

Results

In the H1N1 group, 14 glycerophospholipid metabolites were significantly altered compared to controls, with 11 (78.5%) mark

SUBMITTER: Li Y 

PROVIDER: S-EPMC12006178 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature