Aerobic oxidative bromination and iodination enabled by alloxan and ascorbic acid to mimic flavin-dependent halogenases.

ABSTRACT: The fundamentally significant halogenation processes in organic synthesis heavily depend on the use of hazardous and toxic elemental halogens directly or indirectly, inevitably increasing environmental burden and leading to various production problems. Flavin-dependent halogenases (FDHs) in nature produce organic halides under benign conditions, yet their practical application remained elusive and difficult to scale up. Inspired by FDHs, here we develop a mild and eco-friendly biomimetic aerobic oxidative halogenation strategy that utilizes O₂ from the air to oxidize non-toxic halide salts as a safer alternative. Using simple alloxan as catalyst and low-cost ascorbic acid as reductant, we successfully emulate the challenging flavoenzymatic aerobic halogenation cycle without requ

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12006302 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature