In vitro cytotoxicity evaluation of a CMC-SA edible packaging film for migration and safety assessment.

ABSTRACT: Edible raw materials have gained attention as sustainable food packaging films, which are often considered a priori safe for human consumption. However, cytotoxicity issues may arise due to the incorporation of additives or modifications of film functionality during the manufacturing process. This study introduces an integrated methodology for the evaluation of potential migration of cytotoxic substances from materials used for the development of conventional and biodegradable food packaging. Carboxymethyl cellulose (CMC) and sodium alginate (SA) were tested as raw materials of an edible (CMC-SA) film, while a low-density-polyethylene (LDPE) film was tested as a conventional material. The CMC-SA film exhibited higher water vapor transmission rate and water vapor permeability, and lower hyd

SUBMITTER: Kalliampakou KI 

PROVIDER: S-EPMC12006323 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature