Structural and functional changes of insula subregions in migraine without aura and their relationships with pain perception.

ABSTRACT: Migraine is a highly prevalent and disabling neurological disorder characterized by abnormal encoding of pain perception, linked to structural and functional abnormalities in the insula. Insular subregions play critical but distinct roles in this process, however, the specific patterns and mechanisms remain elusive in migraineurs. In this study, voxel-based morphometry and seed-based functional connectivity (FC) were employed to investigate structural and functional alterations in insula subdivisions in 44 patients with migraine without aura (MWoA) compared with 51 matched healthy controls. Pain perception was evaluated using the intensity, frequency, and duration of migraine. Compared with healthy controls, patients exhibited(1) reduced gray matter volume in the bilateral dorsal anterior

SUBMITTER: Wang X 

PROVIDER: S-EPMC12006336 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature