Functional T cell response to COVID-19 vaccination with or without natural infection with SARS-CoV-2 in adults and children.

ABSTRACT: Severe COVID-19 is rare in children suggesting differences in immune response between children and adults. Limited information is available on how cellular immunity is modulated by COVID-19 vaccination and prior infection, and whether it is differentially modulated in children compared to adults. Here, we aimed to compare COVID-19 vaccine-induced functional T cell response between adults and children with and without previous SARS-CoV-2 infection. Adults (18-45 years; n = 45) and children (5-10 years; n = 51;), who received Pfizer-BioNTech COVID-19 vaccine or remained unvaccinated, and previously infected or not with SARS-CoV-2 were selected from two cross-sectional SARS-CoV-2 serosurveillance studies conducted in Bangladesh. Plasma nucleocapsid (N)-specific antibodies were measured by ele

SUBMITTER: Akhtar E 

PROVIDER: S-EPMC12006499 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature