Liraglutide inhibits the proliferation of rat hepatic stellate cells under high glucose conditions by suppressing the ERK signaling pathway.

ABSTRACT: Liver fibrosis is a common complication of diabetes. Due to the crucial role of HSCs in the pathogenesis of hepatic fibrosis, they are considered a key target in anti-fibrosis research. We designed this experiment to investigate the effects of liraglutide on the proliferation of rat hepatic stellate cells under high glucose conditions and its relationship with the extracellular regulated protein kinases (ERK) signaling pathway. Rat hepatic stellate cells were randomly assigned to five groups: the normal glucose control group, the high glucose control group, the high osmotic group, the high glucose + liraglutide group (referred to as the liraglutide group), and the high glucose + inhibitor group referred to as the inhibitor group). The five groups of cells were cultured for 48 h before proc

SUBMITTER: Fan B 

PROVIDER: S-EPMC12006524 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature