Cost-effectiveness of swab versus tissue sampling for infected diabetic foot ulcers from the CODIFI2 randomised controlled trial.

ABSTRACT:

Aims

To compare the cost-effectiveness of wound swabbing versus tissue sampling for infected diabetic foot ulcers.

Methods

This multi-centre, Phase III, prospective, unblinded, two-arm parallel group, randomised controlled trial compared clinical (reported elsewhere) and economic outcomes of swab versus tissue sampling over a 52-104 week period. Resource use was logged using case record forms and patient questionnaire at weeks 4, 12, 26, 39, 52 and 104, costed using laboratory and published sources from the UK NHS perspective, at 2021/2022 price-year. EQ-5D-3L questionnaires issued at these time points were used to derive quality-adjusted life-years (QALYs). To account for imbalances such as age, a regression-based approach was used to estimate survival, expected costs and Q

SUBMITTER: Bojke C 

PROVIDER: S-EPMC12006556 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature