Association between type 2 diabetes and gastric cancer in Europeans and East Asians based on two sample Mendelian randomization.

ABSTRACT:

Background

There are conflicting results and potential methodological flaws of previous observational studies on the association between T2DM and the risk of gastric cancer.This two-sample Mendelian randomization (MR) study aimed to investigate the causal association between type 2 diabetes mellitus (T2DM) and gastric cancer in different ethnic populations.

Methods

Exposure variables were obtained from genome-wide association studies (GWAS) of T2DM in European population (finn-b-E4_DM2; 32,469) and East Asian population (ebi-a-GCST90018706; n = 45,383). Concomitantly, we utilized summary-level genetic data for gastric cancer in Europeans population (ebi-a-GCST90018849; n = 1029) and East Asians population (ebi-a-GCST90018629; n = 7,921) as the outcome measure. Causal associa

SUBMITTER: Wang X 

PROVIDER: S-EPMC12006575 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature