Gene expression profiling and pathway analysis in head and neck squamous cell carcinoma: focus on disulfidptosis.

ABSTRACT: This study aimed to characterize the prognostic and therapeutic implications of disulfidptosis-related genes (DRGs) in head and neck squamous cell carcinoma (HNSCC). Using multi-omics data from the Cancer Genome Atlas (TCGA) (n = 500) and Gene Expression Omnibus (GEO) cohorts (n = 270), we performed unsupervised consensus clustering, functional enrichment, immune deconvolution, and survival analyses to identify DRG-driven molecular subtypes. A disulfidptosis score (DRGscore) was developed via principal component analysis of prognosis-associated genes and validated across immunotherapy cohorts. Key results revealed eight DRGs with prognostic significance (P < 0.05), including RAC1 and SLC7A11, which form interaction networks linked to redox regulation and immune evasion. Four DRGclusters st

SUBMITTER: Tong Y 

PROVIDER: S-EPMC12006595 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature