Computational repurposing of polyphenols for anti-Mpoxviral activity.

ABSTRACT: Mpox is a globally prevalent disease that has triggered multiple epidemics over the past few decades, leading to moderate rates of hospitalisation and mortality. Recently, it has re-emerged in several countries, including the Democratic Republic of Congo, and appears to be spreading at an unprecedented pace. The disease is caused by zoonotic double-stranded DNA viruses. Due to its similarities with smallpox, distinguishing between the two can be challenging, though the smallpox vaccine typically provides immunity against Mpox. At the time of writing, no approved treatment for Mpox exists; however, several promising candidates have demonstrated the ability to inhibit viral replication, including resveratrol-a polyphenolic compound found in red wine. This study employs molecular docking and

SUBMITTER: Astakala RV 

PROVIDER: S-EPMC12006622 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature