Higher density of compact B cell clusters in invasive front may contribute to better prognosis in pancreatic ductal adenocarcinoma.

ABSTRACT: While the correlation between T cells and patient survival was widely investigated, the clinical significance of CD20⁺ B cells in pancreatic ductal adenocarcinoma (PDAC) is less clear. We hypothesized that the spatial pattern of B cells within tumor microenvironment (TME) are more informative, which may reveal the prognostic significance for PDAC patients. Therefore, we developed a computer-based workflow to analyze CD20⁺ B cells in whole slide images (WSI) from 45 cases of PDAC patients. Depending on this workflow, annotations of each case which were created by pathologists were subdivided for three regions, including invasive front (IF), cancer center (CT) and cancer island (CI) to explore the association between the spatial pattern of CD20⁺ B cells and p

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12006623 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature